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We chose to keep this paragraph in the manuscript as it describes a key observation that provides support for Tyr as a possible regulatory checkpoint. Site 5. Our studies reveal that EZH2 is regulated by methylation-dependent proteolysis, which is negatively controlled by AKT-mediated S21 phosphorylation to establish a methylation-phosphorylation switch to control the PRC2 activity and hematopoiesis. Response: As mentioned earlier, while participants appear heterogeneous in terms of their individual backgrounds and domains of expertise, they are homogenous in terms of the purpose of coming together and being selected as IEC members � ie.